The Smoldyn User Community

Smoldyn is an open research tool that anyone may use. Because Smoldyn can be downloaded without registering, we do not know how many people use it. However, web site statistics (available here) show that Smoldyn is downloaded about 2.5 times per day on average. Other metrics are to quantify scientific citations to Smoldyn or scientific papers published that reported the use of Smoldyn simulations. Those are listed on the publications web page.

Smoldyn users generally fall into 3 classes: (1) computational and experimental biologists who study cell systems, (2) researchers who study the biophysics of relatively simple phenomena, such as macromolecular crowding or multisite receptor phosphorylation, and (3) simulation method developers, who work on particle-based or other simulation methods.

Feedback from users is absolutely essential for continued Smoldyn development, so please do not hesitate to e-mail us ( A large fraction of the features that Smoldyn offers were added in response to requests from users, and we will continue to add requested features, as possible. Also, we like to know who our users are, so that we can target development to meet their needs, so we can tell them about releases, and because information about them can help us raise money for continued development.

The Smoldyn Development Team

Principal investigator

Prior developers



Smoldyn development has been funded by a Simons Foundation grant awarded to Steve Andrews and by research grants from the NIH, DOE, MITRE, and the NSF that were not specifically targeted for Smoldyn. A colleague and I are applying for an NIH R01 which will hopefully fund some work on dynamic surfaces and GPU parallelization.

Upcoming development, depending on funding, includes: (1) add support for biological filaments, such as cytoskeletal filaments and DNA, (2) add support for dynamic surfaces to enable simulation of cell division, cell motility, etc., and (3) accelerate all of Smoldyn by about 200x using graphics processing units.

We will be delighted to add features to Smoldyn if users come up with the funding for their development. Other funding offers, collaborations, or suggestions are very welcome, of course.